General Cell Based Assays
Revvity Health Sciences Inc HTRF Human Phospho-p53 (Ser15) Detection Kit, 96 Assay Points
HTRF Human Phospho-p53 (Ser15) Detection Kit, 96 Assay Points
Cayman Chemical NFAT AcTVatIon InHBTr III 25mg
A cell-permeant inhibitor of NFAT signaling; binds calcineurin (Kd = 0.8 µM), preventing it from dephosphorylating NFAT
ABclonal Technology PLTP Rabbit mAb
The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene.
Abcam SREBP-2 Transcription Factor Assay Kit.
SREBP-2 Transcription Factor Assay Kit.
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical LIpoxygenase InhIbItr Screen
An inhibitor of DNA-PK inhibits radiation-induced increases in phosphorylated DNA-PK levels in U251 and NSC11 cells at 250 or 500 nM induces mutagenic NHEJ and homologous recombination DNA repair pathways in a reporter assay using U2OS cells at 1 UM potentiates radiation-induced cytotoxicity and DNA damage in U251 and NSC11 cells when used at concentrations of 250 or 500 nM increases survival in combination with radiation in a U251 orthotopic mouse xenograft model at 50 mg/kg twice per day
Sigma Aldrich Fine Chemicals Biosciences fluorometric Intracellular
Reactive oxygen species (ROS) are generated as a result of the reduction of oxygen during aerobic respiration and by various enzymatic systems within the cell. At physiological levels ROS contribute to cell signaling and host defense. Increased ROS generation above the detoxification capacity of the biological system results in oxidative stress and cellular damage. The main damage to cells results from the ROS-induced alteration of macromolecules such as polyunsaturated fatty acids in membrane lipids essential proteins and DNA. ROS has been implicated in disease states such as Alzheimer disease Parkinson disease cancer and aging.
Sigma Aldrich Fine Chemicals Biosciences Phosphate Assay Kit suffic
Phosphate is one of the most abundant minerals in the human body and contains about 1 % of total body weight. Phosphate homeostasis is maintained by the several regulators such as parathyroid hormone (PTH) calcitriol and phosphatonins. Maintenance of phosphate homeostasis is essential for various biological processes such as energy metabolism cell signaling regulation of protein synthesis skeletal development and bone integrity. An adequate level of phosphate is needed for the process of apoptosis of mature chondrocytes in the growth plate. Phosphate deficiency is associated with the bone pathology and clinical illness.
Cayman Chemical NBD-Fructose 500UG
A fluorescent derivative of fructose; has been used to monitor fructose uptake by the GLUT5 transporter in MCF-7, MDA-MB-435, and MDA-MB-231 human breast cancer cells; ex/em = 472/538 nm, respectively
Montana Molecular Green Cilia-targeted cADDis cAMP Assay - 10mL
Measure real-time cAMP signaling kinetics in the primary cilia with this live cell fluorescent assay. Add 5HT6-tagged cADDis to your cells and measure robust signals the next day on a fluorescence imaging system. Decreasing green fluorescence indicates ciliary cAMP increase. This assay is genetically encoded and packaged in BacMam for efficient transduction in most cell types - including uniform and near 100% efficiency in HEK293 cells as well as expression in many primary or iPSC-derived cells. The kit includes the cilia-targeted cAMP sensor BacMam and 500mM sodium butyrate in H2O.
Eurofins Discoverx cAMP Hunter eXpress PTGER3 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0159E2CP2M)
The cAMP Hunter PTGER3 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. prostaglandin E2, cloprostenol) based activation of PTGER3 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type PTGER3, a naturally Gi/Go coupled GPCR. Upon activation of PTGER3, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Eurofins Discoverx cAMP Hunter eXpress GRM2 CHO-K1 GPCR Assay, 2-Plate Kit. (95-0148E2CP23M)
The cAMP Hunter GRM2 eXpress kit provides an easy-to-use cell based assay to study drug candidates (small molecules or biologics) targeting GPCRs. This kit assesses ligand (e.g. L-glutamate) based activation of GRM2 GPCR activity via detection of decreasing levels of intracellular cAMP. This product uses EFC technology. The cells overexpress wild type GRM2, a naturally Gi/Go coupled GPCR. Upon activation of GRM2, the decrease in levels of intracellular cAMP leads to a decreased signal from EFC when the cAMP detection kit is applied. eXpress kits are a convenient, ready-to-use format which contains all materials needed to run the assay, including single-use vials of cryopreserved cells, cell plating media, detection reagent, and assay plates. For detailed product information, User Manual and Datasheet, visit www.discoverx.com/express.
Arbor Assays Catalase Colorimetric Activity Kit (2 Plate)
The DetectX Catalase Colorimetric Activity Kit quantitatively measures catalase activity in any sample and includes everything needed to measure catalase activity in 45 minutes.
